European Virtual Human Twin

Both Mechanistic and data-driven approaches|

Data-driven approaches|

Mechanistic approaches|

Stroke|

Herrgårdh, Tilda, Elizabeth Hunter, Kajsa Tunedal, Håkan Örman, Julia Amann, Francisco Abad Navarro, Catalina Martinez-Costa, John D. Kelleher, and Gunnar Cedersund. ‘Digital Twins and Hybrid Modelling for Simulation of Physiological Variables and Stroke Risk’. Preprint. Systems Biology, 27 March 2022.

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Bone (orthopaedics)|

Both Mechanistic and data-driven approaches|

Cell related|

Data-driven approaches|

Mechanistic approaches|

Opinion/commentary|

Software|

Hernigou, Philippe, and Marius M. Scarlat. ‘Ankle and Foot Surgery: From Arthrodesis to Arthroplasty, Three Dimensional Printing, Sensors, Artificial Intelligence, Machine Learning Technology, Digital Twins, and Cell Therapy’. International Orthopaedics 45, no. 9 (September 2021): 2173–76.

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Bone (orthopaedics)|

Both Mechanistic and data-driven approaches|

Data-driven approaches|

Mechanistic approaches|

Software|

Hernigou, Philippe, Romain Olejnik, Adonis Safar, Sagi Martinov, Jacques Hernigou, and Bruno Ferre. ‘Digital Twins, Artificial Intelligence, and Machine Learning Technology to Identify a Real Personalized Motion Axis of the Tibiotalar Joint for Robotics in Total Ankle Arthroplasty’. International Orthopaedics 45, no. 9 (September 2021): 2209–17.

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Both Mechanistic and data-driven approaches|

Data-driven approaches|

Mechanistic approaches|

Spine|

He, Xiwang, Yiming Qiu, Xiaonan Lai, Zhonghai Li, Liming Shu, Wei Sun, and Xueguan Song. ‘Towards a Shape-Performance Integrated Digital Twin for Lumbar Spine Analysis’. Digital Twin 1 (5 November 2021): 8.

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Both Mechanistic and data-driven approaches|

Cancer|

Data-driven approaches|

Mechanistic approaches|

Review articles|

HamlAbadi, Kamran Gholizadeh, Monireh Vahdati, Ali Mohammad Saghiri, and Agostino Forestiero. ‘Digital Twins in Cancer: State-of-the-Art and Open Research’. In 2021 IEEE/ACM Conference on Connected Health: Applications, Systems and Engineering Technologies (CHASE), 199–204. Washington, DC, USA: IEEE, 2021.

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Both Mechanistic and data-driven approaches|

Cell related|

Data-driven approaches|

Mechanistic approaches|

Opinion/commentary|

Tissue engineering|

Geris, Liesbet, Toon Lambrechts, Aurélie Carlier, and Ioannis Papantoniou. ‘The Future Is Digital: In Silico Tissue Engineering’. Current Opinion in Biomedical Engineering 6 (June 2018): 92–98

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Both Mechanistic and data-driven approaches|

Cancer|

Data-driven approaches|

Mechanistic approaches|

Corral-Acero, Jorge, Francesca Margara, Maciej Marciniak, Cristobal Rodero, Filip Loncaric, Yingjing Feng, Andrew Gilbert, et al. ‘The “Digital Twin” to Enable the Vision of Precision Cardiology’. European Heart Journal 41, no. 48 (21 December 2020): 4556–64

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Both Mechanistic and data-driven approaches|

Cardiovascular|

Data-driven approaches|

Mechanistic approaches|

Chakshu, Neeraj Kavan, Igor Sazonov, and Perumal Nithiarasu. ‘Towards Enabling a Cardiovascular Digital Twin for Human Systemic Circulation Using Inverse Analysis’. Biomechanics and Modeling in Mechanobiology 20, no. 2 (April 2021): 449–65

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Both Mechanistic and data-driven approaches|

Data-driven approaches|

Ethics|

Mechanistic approaches|

Opinion/commentary|

Policy|

Braun, Matthias, and Jenny Krutzinna. ‘Digital Twins and the Ethics of Health Decision-Making Concerning Children’. Patterns 3, no. 4 (April 2022): 100469.

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Both Mechanistic and data-driven approaches|

Data-driven approaches|

Ethics|

Mechanistic approaches|

Braun, Matthias. ‘Represent Me: Please! Towards an Ethics of Digital Twins in Medicine’. Journal of Medical Ethics 47, no. 6 (June 2021): 394–400

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