European Virtual Human Twin

Both Mechanistic and data-driven approaches|

Data-driven approaches|

Mechanistic approaches|

Opinion/commentary|

Pandemic (virus related)|

Laubenbacher, Reinhard, James P. Sluka, and James A. Glazier. ‘Using Digital Twins in Viral Infection’. Science 371, no. 6534 (12 March 2021): 1105–6.

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Both Mechanistic and data-driven approaches|

Data-driven approaches|

Immune system|

Mechanistic approaches|

Opinion/commentary|

Laubenbacher, R., A. Niarakis, T. Helikar, G. An, B. Shapiro, R. S. Malik-Sheriff, T. J. Sego, A. Knapp, P. Macklin, and J. A. Glazier. ‘Building Digital Twins of the Human Immune System: Toward a Roadmap’. Npj Digital Medicine 5, no. 1 (December 2022): 64.

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Both Mechanistic and data-driven approaches|

Data-driven approaches|

Mechanistic approaches|

Opinion/commentary|

Pandemic (virus related)|

Review articles|

Khan, Asiya, Madison Milne-Ives, Edward Meinert, Gloria E Iyawa, Ray B Jones, and Alex N Josephraj. ‘A Scoping Review of Digital Twins in the Context of the Covid-19 Pandemic’. Biomedical Engineering and Computational Biology 13 (January 2022): 117959722211021.

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Cardiovascular|

Mechanistic approaches|

Jung, Alexander, Matthias A. F. Gsell, Christoph M. Augustin, and Gernot Plank. ‘An Integrated Workflow for Building Digital Twins of Cardiac Electromechanics—A Multi-Fidelity Approach for Personalising Active Mechanics’. Mathematics 10, no. 5 (4 March 2022): 823.

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Both Mechanistic and data-driven approaches|

Data-driven approaches|

Mechanistic approaches|

Stroke|

Herrgårdh, Tilda, Elizabeth Hunter, Kajsa Tunedal, Håkan Örman, Julia Amann, Francisco Abad Navarro, Catalina Martinez-Costa, John D. Kelleher, and Gunnar Cedersund. ‘Digital Twins and Hybrid Modelling for Simulation of Physiological Variables and Stroke Risk’. Preprint. Systems Biology, 27 March 2022.

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Bone (orthopaedics)|

Both Mechanistic and data-driven approaches|

Cell related|

Data-driven approaches|

Mechanistic approaches|

Opinion/commentary|

Software|

Hernigou, Philippe, and Marius M. Scarlat. ‘Ankle and Foot Surgery: From Arthrodesis to Arthroplasty, Three Dimensional Printing, Sensors, Artificial Intelligence, Machine Learning Technology, Digital Twins, and Cell Therapy’. International Orthopaedics 45, no. 9 (September 2021): 2173–76.

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Bone (orthopaedics)|

Both Mechanistic and data-driven approaches|

Data-driven approaches|

Mechanistic approaches|

Software|

Hernigou, Philippe, Romain Olejnik, Adonis Safar, Sagi Martinov, Jacques Hernigou, and Bruno Ferre. ‘Digital Twins, Artificial Intelligence, and Machine Learning Technology to Identify a Real Personalized Motion Axis of the Tibiotalar Joint for Robotics in Total Ankle Arthroplasty’. International Orthopaedics 45, no. 9 (September 2021): 2209–17.

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Cancer|

Mechanistic approaches|

Opinion/commentary|

Hernandez-Boussard, Tina, Paul Macklin, Emily J. Greenspan, Amy L. Gryshuk, Eric Stahlberg, Tanveer Syeda-Mahmood, and Ilya Shmulevich. ‘Digital Twins for Predictive Oncology Will Be a Paradigm Shift for Precision Cancer Care’. Nature Medicine 27, no. 12 (December 2021): 2065–66.

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Cell related|

Mechanistic approaches|

Pandemic (virus related)|

Pharmaceutical (drug development etc.)|

Helgers, Heribert, Alina Hengelbrock, Axel Schmidt, and Jochen Strube. ‘Digital Twins for Continuous MRNA Production’. Processes 9, no. 11 (4 November 2021): 1967.

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Both Mechanistic and data-driven approaches|

Data-driven approaches|

Mechanistic approaches|

Spine|

He, Xiwang, Yiming Qiu, Xiaonan Lai, Zhonghai Li, Liming Shu, Wei Sun, and Xueguan Song. ‘Towards a Shape-Performance Integrated Digital Twin for Lumbar Spine Analysis’. Digital Twin 1 (5 November 2021): 8.

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