Materials

Roadmap

Community of Practice

The VHT Manifesto: A Statement of Intent on Development, Evidence, and Adoption in Healthcare Systems

Deliverable 3.1: Vision for the Virtual Human Twin and Roadmap Outline

Deliverable 3.2: First Draft of the VHT Roadmap

Deliverable 6.2: Towards a Code of Conduct for the re-use and integration of Virtual Human Twins: analysis of the legal landscape and identification of legal and ethical challenges

Brochure
Brochure illustrating EDITH vision, mission and objectives

Building the European Virtual Human Twin

First Ecosystem Meeting on Building the VHT

Deep Thinkers Meeting

M. Golebiewski, G. Mayer, SO/AWI 23494-2 Biotechnology — Provenance information model for biological material and data Part 2: Common Provenance Model, (Dec. 2024), International Organization for Standardization

M. Golebiewski, G. Mayer, Data Formats for Systems Biology, Systems Medicine and Computational Modeling, (Dec. 2024), Elsevier

L. Cristofaro, R. Traina Chiarini, F. Jung, S. Denil, M. Golebiewski, G. Mayer, F. Conte, Towards a Code of Conduct for the re-use and integration of Virtual Human Twins: analysis of the legal landscape and identification of legal and ethical challenges (Dec. 2024), Zenodo

A. Niarakis, R. Laubenbacher, G. An, Y. Ilan, J. Fisher, Å. Flobak, K. Reiche, M. R. Martínez, L. Geris, L. Ladeira, L. Veschini, M. L. Blinov, F. Messina, L. L. Fonseca, S. Ferreira, A. Montagud, V. Noël, M. Marku, E. Tsirvouli, M. M. Torres, L. A. Harris, T. J. Sego, C. Cockrell, A. E. Shick, H. Balci, A. Salazar, K. Rian, A. A. Hemedan, M. Esteban-Medina, B. Staumont, E. Hernandez-Vargas, S. Martis B, A. Madrid-Valiente, P. Karampelesis, L. Sordo Vieira, P. Harlapur, A. Kulesza, N. Nikaein, W. Garira, R. S. M. Sheriff, J. Thakar, V. Du T Tran, J. Carbonell-Caballero, S. Safaei, A. Valencia, A. Zinovyev, J. A. Glazier, Immune digital twins for complex human pathologies: applications, limitations, and challenges, (Nov. 2024), NHI National Library of Medicine

B. Eguzkitza, J. A. Navia, G. Houzeaux, C. Butakoff, M. Vázquez, Performance Assessment of an Electrostatic Filter-Diverter Stent Cerebrovascular Protection Device: Evaluation of a Range of Potential Electrostatic Fields Focusing on Small Particles, (Nov. 2024), Bioengineering

G. Karanasiou, E. Edelman, F.-H. Boissel, R. Byrne, L. Emili, M. Fawdry, N. Filipović, D. Flynn, L. Geris, A. Hoekstra, M. C. Jori, A. Kiapour, D. Krsmanovic, T. Marchal, F. Musuamba, F. Pappalardo, L. Petrini, M. Reiterer, M. Viceconti, K. Zeier, L. K. Michalis, D. I. Fotiadis, Advancing In Silico Clinical Trials for Regulatory Adoption and Innovation, (Nov. 2024), NHI National Library of Medicine

M. Bubak, P. Nowakowski, P. Połeć, A Demonstrator of the European virtual human twin simulation platform, (Sep. 2024), VPH Conference 2024 Book of Abstracts

L. Bevis, S. B. Misghina, E. Rauseo, C. E. Lopez Barrera, G. Plank, E. Vigmond, A. Loewe, E. Karabelas, J. A. Solis-Lemus, S. Niederer, E. E. Steffen, Development of a User-Friendly Pipeline for Constructing Atrial Models at Scale: Importance of the End-User for Clinical Uptake, (Sep. 2024), Computing in Cardiology 2024

M. Mercuri, F. Nardini, C. Curreli, A. A. La Mattina, S. Mellone, M. Viceconti, A user interface to facilitate visualization and integration of predictions for mechanical femur strength, (Sep. 2024), VHP Conference Book of Abstracts

A. M. Salih, I. Boscolo Galazzo, P. Gkontra, E. Rauseo, A. Mark Lee, K. Lekadir, P. Radeva, S. E. Petersen, G. Menegaz, A review of evaluation approaches for explainable AI with applications in cardiology, (Aug. 2024), NHI National Library of Medicine

G. Kotoulas, V. Loukas1, G. Karanasiou, A. Sakellarios, V. Pezoulas, C. Katsouras, L. Michalis, A. Semertzioglou, A. Moulas, L. Geris, D. Fotiadis, In silico drug delivery modeling of a novel Everolimus Coated Balloon, (Jul. 2024), Conference Proceeding EMBC 2024

M. Golebiewski, G. Bader, P. Gleeson, T. E. Gorochowski, S. M. Keating, M. König, C. J. Myers, D. P. Nickerson, B. Sommer, D. Waltemath, F. Schreiber, Specifications of standards in systems and synthetic biology: status, developments, and tools in 2024, (Jul. 2024), Walter de Gruyter

K. Dziopa , K. Lekadir, P. van der Harst, F. W. Asselbergs, Digital twins: reimagining the future of cardiovascular risk prediction and personalised care, (Jun. 2024), NHI National Library of Medicine

O. A. Jaffery, L. Melki, G. Slabaugh, W. W. Good, C. H. Roney, A Review of Personalised Cardiac Computational Modelling Using Electroanatomical Mapping Data, (May 2024), NHI National Library of Medicine

M. Bubak, M. Kasztelnik, M. Malawski, J. Meizner, P. Nowakowski, P. Połec, Research towards Virtual Human Twins, (Mar. 2024), KUKDM Conference Proceedings

A. Niarakis, M. Ostaszewski, A. Mazein, I. Kuperstein, M. Kutmon, M. E. Gillespie, A. Funahashi, M. L. Acencio, A. Hemedan, M. Aichem, K. Klein, T. Czauderna, F. Burtscher, T. G. Yamada, Y. Hiki, N. F. Hiroi, F. Hu, N. Pham, F. Ehrhart, E. L. Willighagen, A. Valdeolivas, A. Dugourd, F. Messina, M. Esteban-Medina, M. Peña-Chilet, K. Rian, S. Soliman, S. S. Aghamiri, B. L. Puniya, A. Naldi, T. Helikar, V. Singh, M. Fariñas Fernández, V. Bermudez, E. Tsirvouli, A. Montagud, V. Noël, M. Ponce-de-Leon, D. Maier, A. Bauch, B. M. Gyori, J. A. Bachman, A. Luna, J. Piñero, L. I. Furlong, I. Balaur, A. Rougny, Y. Jarosz, R. W. Overall, R. Phair, L. Perfetto, L. Matthews, D. A. Balaya Rex, M. Orlic-Milacic, L. C. Monraz Gomez, B. De Meulder, J. M. Ravel, B. Jassal, V. Satagopam, G. Wu, M. Golebiewski, P. Gawron, L. Calzone, J. S. Beckmann, C. T. Evelo, P. D’Eustachio, F. Schreiber, J. Saez-Rodriguez, J. Dopazo, M. Kuiper, A. Valencia, O. Wolkenhauer, H. Kitano, E. Barillot, C. Auffray, R. Balling, R. Schneider, Drug-target identification in COVID-19 disease mechanisms using computational systems biology approaches, (Feb. 2024), Frontiers

A. Bayas, U. Mansmann, B. I. Ön, V. S. Hoffmann, A. Berthele, M. Mühlau, M. C. Kowarik, M. Krumbholz, M. Senel, V. Steuerwald, M. Naumann, J. Hartberger, M. Kerschensteiner, E. Oswald, C. Ruschil, U. Ziemann, H. Tumani, I. Vardakas, F. Albashiti, F. Kramer, Iñaki Soto-Rey, H. Spengler, G. Mayer, H. A. Kestler, O. Kohlbacher, M. Hagedorn, M. Boeker, K. Kuhn, S. Buchka, F. Kohlmayer, J. S. Kirschke, L. Behrens, H. Zimmermann, B. Bender, N. Sollmann, J. Havla, B. Hemmer, Prospective study validating a multidimensional treatment decision score predicting the 24-month outcome in untreated patients with clinically isolated syndrome and early relapsing-remitting multiple sclerosis, the ProVal-MS study, (Mar. 2024), NHI National Library of Medicine

G. Mayer, M. Golebiewski, Standardization landscape, needs and gaps for the virtual human twin (VHT), (Feb. 2024), Internet Archive Scholar

G. Mayer, M. Golebiewski, EDITH standards implementation guide (IG), (Jan. 2024), Internet Archive Scholar

H. Roney, J.A. Solis Lemus, C. Lopez Barrera, A. Zolotarev, O. Ulgen, E. Kerfoot, L. Bevis, S. Misghina, C. Vidal Horrach, O. A. Jaffery, M. Ehnesh, Constructing bilayer and volumetric atrial models at scale, (Dec. 2023), NHI National Library of Medicine

W. R. Punter, O. Papapetrou, M. Garofalakis, OmniSketch: Efficient Multi-Dimensional High-Velocity Stream Analytics with Arbitrary Predicates, (Nov. 2023), ACM Digital Library

M. Viceconti, M. De Vos, S. Mellone, L. Geris, Position paper, From the digital twins in healthcare to the Virtual Human Twin: a moon-shot project for digital health research, (Oct. 2023), NHI National Library of Medicine

G. Mayer, M. Golebiewski Martin, W. Müller, The role of standards in defining an ecosystem for Virtual Human Twins (VHTs), (Sep. 23), Zenodo

ISO/TS 9491-1:2023, Biotechnology — Predictive computational models in personalized medicine research, Part 1: Constructing, verifying and validating models (Jun. 2023), International Organization for Standardization

R. Lesage, M. Van Oudheusden, S. Schievano, I. Van Hoyweghen, L. Geris, C. Capelli, Mapping the use of computational modelling and simulation in clinics: A survey, (Apr. 2023), Frontiers

R. Wittner, P. Holub, C. Mascia, F. Frexia, H. Müller, M. Plass, C. Allocca, F. Betsou, T. Burdett, I. Cancio, A. Chapman, M. Chapman, M. Courtot, V. Curcin, J. Eder, M. Elliot, K. Exter, C. Goble, M. Golebiewski, B. Kisler, A. Kremer, S. Leo, S. Lin-Gibson, A. Marsano, M. Mattavelli, J. Moore, H. Nakae, I. Perseil, A. Salman, J. Sluka, S. Soiland-Reyes, C. Strambio-De-Castillia, M. Sussman, J. R. Swedlow, K. Zatloukal, J. Geiger, Toward a common standard for data and specimen provenance in life sciences, (Apr. 2023), Wiley

ISO/TS 23494-1:2023, Biotechnology — Provenance information model for biological material and data, Part 1: Design concepts and general requirements (Apr. 2023), International Organization for Standardization

ISO 20691:2022, Biotechnology — Requirements for data formatting and description in the life sciences, (Nov. 2022), International Organization for Standardization

EDITH CSA, building the European Virtual Human Twin

What is the Virtual Human Twin?

EDITH Ecosystem

EDITH Use-cases

What are the ethical and legal challenges?

Digital Twins: A surgeon’s perspective

Digital Twins and High Performance Computing

The importance of standards

How is the project proceeding?

A Digital Twin of the heart

Use Case: Human brain

EDITH’s Vision and Roadmap

Data privacy and AI in the Virtual Human Twin

What is the 12 Labours Project at the University of Auckland?

The role of start-ups in EDITH

Use Case: Cardiovascular

Essential elements of the future VHT platform

Use Case: Novel sensing technologies

Digital Twins in the Intensive Care Unit

The European Commission’s vision on the Virtual Human Twin

Patients’ contribution to the Virtual Human Twin

Ethics and the Virtual Human Twins

Bringing the Virtual Human Twin to business

Patients’ role in the development of the Virtual Human Twin

Communicating the Virtual Human Twin

The legacy of EDITH

EDITH deep thinkers meeting in Rome (16-17 May 2023)

EDITH ecosystem meeting in Paris (18-19 January 2024)

EDITH ecosystem meeting in Amsterdam (15-16 July 2024)

Public consultation version of the first draft of the VHT Roadmap